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Predictive Medicine Risk Assessment
CANCER – May 2007
Ralph, DA, Zhao, LP, Aston, CE, Manjeshwar, S, Pugh, TW, DeFreese, DC, Gramling, BA, Shimasaki, CD, Jupe, ER. Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk. CANCER (2007) May 15; 109 (10):1940-1948.
This investigation of steroid hormone pathway genes in a large case-control study has identified and confirmed age-specific genetic associations with breast cancer risk for SNPs in four genes. Age-related associations with risk could have profound implications for the use of SNP genotyping to accurately predict breast cancer risk in women.
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Human Genetics - February 2005
Aston CE, Ralph DA, Lalo DP, Manjeshwar S, Gramling BA, DeFreese DC, West AD, Branam DE, Thompson LF, Craft MA, Mitchell DS, Shimasaki CD, Mulvihill JJ, Jupe ER. Oligogenic combinations associated with breast cancer risk in women under 53 years of age. Human Genetics (2005) Feb; 116(3):208-21.
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Expanded tables from this publication
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San Antonio, TX, December 2004 - View PDF
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Findings - OMRF, Summer 2004
Oklahoma Medical Research Foundation
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Predictive Medicine Archives
Targeted Cancer Therapy
Expression of prohibitin 3' untranslated region suppressor RNA alters morphology and inhibits motility of breast cancer cells - Journal of Molecular Histology 2004
Tumor Suppression by the Prohibitin Gene 3'Untranslated Region RNA in Human Breast Cancer - September 1, 2003, Cancer Research, 2003
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